The role of corticotropin-releasing factor in depression and anxiety disorders
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چکیده
منابع مشابه
The role of corticotropin-releasing factor in depression and anxiety disorders.
Corticotropin-releasing factor (CRF), a 41 amino acid-containing peptide, appears to mediate not only the endocrine but also the autonomic and behavioral responses to stress. Stress, in particular early-life stress such as childhood abuse and neglect, has been associated with a higher prevalence rate of affective and anxiety disorders in adulthood. In the present review, we describe the evidenc...
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15 صفحه اولDeciphering the interaction of the corticotropin-releasing factor and serotonin brain systems in anxiety-related disorders.
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متن کاملOn the role of corticotropin-releasing hormone receptors in anxiety and depression
On the basis of extensive basic and clinical studies, corticotropin-releasing hormone (CRH) and its related family members are considered to play a pivotal role in stress-related disorders, such as anxiety and depression. CRH is regarded as the principal mediator in the brain of the stress response, as it mediates neuroendocrine, autonomic, and behavioral responses to stressful challenges. Rece...
متن کاملThe role of corticotropin-releasing factor receptors in stress and anxiety.
Corticotropin releasing factor (CRF) is a critical integrator of the hypothalamic-pituitary-adrenal (HPA) axis in response to stress. CRF and its related molecule urocortin (UCN) bind CRF receptor 1 (CRFR1) and CRFR2 with distinct affinities. Mice deficient for CRFR1 or CRFR2 were generated in order to determine the physiological role of these receptors. While CRFR1-mutant mice show a depleted ...
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ژورنال
عنوان ژورنال: Journal of Endocrinology
سال: 1999
ISSN: 0022-0795,1479-6805
DOI: 10.1677/joe.0.1600001